Bernadette is a frightfully intelligent wife and mother whose intense allergy to Seattle specifically, and to people in general, has driven her to hire a virtual assistant in India to execute even her most basic tasks. Then her daughter, Bee, insists on a family trip to Antarctica as her reward for getting perfect grades in middle school, and Bernadette is faced with the daunting prospect of actual human interaction. And then Bernadette disappears....

Eleven-year-old Kyna, terrified of water since her family drowned in a storm that nearly took her life as well, works to overcome her phobia when her adoptive parents, Irish immigrants with a mysterious past, rent a cabin on Lake Champlain for the summer.

Thirteen-year-olds Madeleine, Theo, and Lulu, fourteen-year-old Garrison, and ten-year-old new "contestant" Hyacinth, must face their phobias and join forces to learn who is stealing wigs and pageant trophies from the School of Fear.

When a reporter plans an expos that could shut down the School of Fear, Garrison, Lulu, Madeleine, and Theo seek help from Bishop Basmati, head of the nearby Contrary Academy, whose hyperactive, fearless, and extremely impulsive students soon overrun the School of Fear.

Ten-year-old Jamie Jo's fear of bees keeps her inside most of the time, but a series of events that begins when her mother is excluded from the church choir brings about many changes, including new friendships and greater trust in God.